Levitra Indication:

Used for the treatment of erectile dysfunction

Levitra Mechanism Of Action:

Levitra inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

Levitra Drug Interactions:

Not Available

Levitra Food Interactions:

Not Available

Levitra Generic Name:

Synonyms:

  • VDN

Drug Type:

Small Molecule; Approved

Absorption:

Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Toxicity (Overdose):

Symptoms of overdose include vision changes and back and muscle pain.

Protein Binding:

95%

Biotransformation:

Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil.

Half Life:

4-5 hours

Dosage Forms of Levitra:

Tablet Oral

Chemical IUPAC Name:

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

Organisms Affected:

Humans and other mammals

Levitra to general, pharmacology

General, pharmacology..
Men's Health