Lexapro Indication:

For the treatment of major depressive disorder and Generalized Anxiety Disorder (GAD).

Lexapro Mechanism Of Action:

The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Lexapro blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Lexapro Drug Interactions:

Almotriptan Increased risk of CNS adverse effects
Eletriptan Increased risk of CNS adverse effects
Carvedilol The SSRI increases the effect of the beta-blocker
Frovatriptan Increased risk of CNS adverse effects
Isocarboxazid Possible severe adverse reaction with this combination
Linezolid Combination associated with possible serotoninergic syndrome
Naratriptan Increased risk of CNS adverse effects
Metoprolol The SSRI increases the effect of the beta-blocker
Pimozide The SSRI increases the effect of the beta-blocker
Oxycodone Increased risk of serotonin syndrome
Phenelzine Possible severe adverse reaction with this combination
Rasagiline Possible severe adverse reaction with this combination
Selegiline Possible severe adverse reaction with this combination
Tranylcypromine Possible severe adverse reaction with this combination
Rizatriptan Increased risk of CNS adverse effects
Sumatriptan Increased risk of CNS adverse effects
Zolmitriptan Increased risk of CNS adverse effects
Sibutramine Risk of serotoninergic syndrome
Tramadol Increased risk of serotonin syndrome
St. John's Wort St. John's Wort increases the effect and toxicity of the SSRI
Propranolol The SSRI increases the effect of the beta-blocker

Lexapro Food Interactions:

Take without regard to meals.

Lexapro Generic Name:

Synonyms:

  • Escitalopram Oxalate

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

The absolute bioavailability of citalopram is about 80% relative to an intravenous dose

Toxicity (Overdose):

Signs of overdose include convulsions, coma, dizziness, hypotension, insomnia, nausea, vomiting, sinus tachycardia, somnolence, and ECG changes (including QT prolongation).

Protein Binding:

~56%

Biotransformation:

Mainly hepatic. Escitalopram undergoes N-demethylation to S-demethylcitalopram (S-DCT) and S-didemethylcitalopram (S-DDCT). CYP3A4 and CYP2C19 are the enzymes responsible for this N-demethylation.

Half Life:

27-32 hours

Dosage Forms of Lexapro:

Tablet Oral

Chemical IUPAC Name:

(1S)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile

Organisms Affected:

Humans and other mammals

Lexapro to general, pharmacology

General, pharmacology..
Depression