Lopressor Indication:

For the treatment of hypertension and angina pectoris.

Lopressor Mechanism Of Action:

Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

Lopressor Drug Interactions:

Acetohexamide The beta-blocker decreases the symptoms of hypoglycemia
Chlorpropamide The beta-blocker decreases the symptoms of hypoglycemia
Cimetidine Cimetidine increases the effect of the beta-blocker
Clonidine Increased hypertension when clonidine stopped
Disopyramide The beta-blocker increases toxicity of disopyramide
Gliclazide The beta-blocker decreases the symptoms of hypoglycemia
Glipizide The beta-blocker decreases the symptoms of hypoglycemia
Glisoxepide The beta-blocker decreases the symptoms of hypoglycemia
Glibenclamide The beta-blocker decreases the symptoms of hypoglycemia
Glycodiazine The beta-blocker decreases the symptoms of hypoglycemia
Insulin The beta-blocker decreases the symptoms of hypoglycemia
Lidocaine The beta-blocker increases the effect and toxicity of lidocaine
Propafenone Propafenone increases the effect of beta-blocker
Repaglinide The beta-blocker decreases the symptoms of hypoglycemia
Rifampin Rifampin decreases the effect of the metabolized beta-blocker
Telithromycin Telithromycin may possibly increase metoprolol effect
Tolazamide The beta-blocker decreases the symptoms of hypoglycemia
Tolbutamide The beta-blocker decreases the symptoms of hypoglycemia
Amobarbital The barbiturate decreases the effect of metabolized beta-blocker
Aprobarbital The barbiturate decreases the effect of metabolized beta-blocker
Butalbital The barbiturate decreases the effect of metabolized beta-blocker
Butabarbital The barbiturate decreases the effect of metabolized beta-blocker
Butethal The barbiturate decreases the effect of metabolized beta-blocker
Dihydroquinidine barbiturate The barbiturate decreases the effect of metabolized beta-blocker
Heptabarbital The barbiturate decreases the effect of metabolized beta-blocker
Hexobarbital The barbiturate decreases the effect of metabolized beta-blocker
Methohexital The barbiturate decreases the effect of metabolized beta-blocker
Methylphenobarbital The barbiturate decreases the effect of metabolized beta-blocker
Pentobarbital The barbiturate decreases the effect of metabolized beta-blocker
Phenobarbital The barbiturate decreases the effect of metabolized beta-blocker
Primidone The barbiturate decreases the effect of metabolized beta-blocker
Quinidine barbiturate The barbiturate decreases the effect of metabolized beta-blocker
Secobarbital The barbiturate decreases the effect of metabolized beta-blocker
Talbutal The barbiturate decreases the effect of metabolized beta-blocker
Citalopram The SSRI increases the effect of the beta-blocker
Escitalopram The SSRI increases the effect of the beta-blocker
Fluoxetine The SSRI increases the effect of the beta-blocker
Sertraline The SSRI increases the effect of the beta-blocker
Paroxetine The SSRI increases the effect of the beta-blocker
Dihydroergotamine Ischemia with risk of gangrene
Dihydroergotoxine Ischemia with risk of gangrene
Ergonovine Ischemia with risk of gangrene
Ergotamine Ischemia with risk of gangrene
Methysergide Ischemia with risk of gangrene
Verapamil Increased effect of both drugs
Hydralazine Increased effect of both drugs
Diltiazem Increased risk of bradycardia
Epinephrine Hypertension, then bradycardia
Fenoterol Antagonism
Formoterol Antagonism
Isoproterenol Antagonism
Orciprenaline Antagonism
Pirbuterol Antagonism
Prazosin Risk of hypotension at the beginning of therapy
Procaterol Antagonism
Salbutamol Antagonism
Salmeterol Antagonism
Terbutaline Antagonism
Ibuprofen Risk of inhibition of renal prostaglandins
Indomethacin Risk of inhibition of renal prostaglandins
Piroxicam Risk of inhibition of renal prostaglandins

Lopressor Food Interactions:

Avoid alcohol.
Take with food.
Avoid natural licorice.

Lopressor Generic Name:

Synonyms:

  • Metoprolol Tartrate
  • Metoprolol succinate

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

Rapid and complete, 50%

Toxicity (Overdose):

LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)

Protein Binding:

12%

Biotransformation:

Primarily hepatic

Half Life:

3-7 hours

Dosage Forms of Lopressor:

Solution Intravenous
Liquid Intravenous
Tablet, extended release Oral
Tablet Oral

Chemical IUPAC Name:

1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Organisms Affected:

Humans and other mammals

Lopressor to general, pharmacology

General, pharmacology..
Blood Pressure