Lorex Indication:

For the short-term treatment of insomnia.

Lorex Mechanism Of Action:

Lorex modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABAA receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Lorex preferentially binds to the alpha-1 receptor.

Lorex Drug Interactions:

Not Available

Lorex Food Interactions:

Avoid alcohol.
Take 30-60 minutes before breakfast.

Lorex Generic Name:

Synonyms:

  • Zolpidemum [Latin]
  • Zolpidem tartrate

Drug Type:

Small Molecule; Approved

Absorption:

Zolpidem is rapidly absorbed from the GI tract.

Toxicity (Overdose):

Oral (male rat) LD50 = 695 mg/kg. Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma.

Protein Binding:

92.5 ± 0.1% (independent of concentration between 40 and 790 ng/mL)

Biotransformation:

Zolpidem is converted to inactive metabolites in the liver.

Half Life:

2.6 hours

Dosage Forms of Lorex:

Tablet Oral

Chemical IUPAC Name:

N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[3,2-a]pyridin-3-yl]acetamide

Organisms Affected:

Humans and other mammals

Lorex to general, pharmacology

General, pharmacology..