Lotensin

Lotensin, brand name Lotensin®, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.


Most likely, Lotensin - a mixture:
Lotensin HCT (Benazepril Hydrochloride + Hydrochlorothiazide)

Medicinal name:
  • Benazepril hydrochloride 20 MG / Hydrochlorothiazide 12.5 MG Oral Tablet [Lotensin HCT]
  • Benazepril hydrochloride 20 MG / Hydrochlorothiazide 25 MG Oral Tablet [Lotensin HCT]
  • Benazepril hydrochloride 20 MG Oral Tablet [Lotensin]
  • Benazepril hydrochloride 40 MG Oral Tablet [Lotensin]
  • Benazepril hydrochloride 10 MG Oral Tablet [Lotensin]
  • Benazepril hydrochloride 5 MG Oral Tablet [Lotensin]
  • Benazepril hydrochloride 10 MG / Hydrochlorothiazide 12.5 MG Oral Tablet [Lotensin HCT]

Lotensin - Pharmacology:

Lotensinat, the active metabolite of Lotensin, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Lotensinat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Lotensin mini report

Lotensin NDA
NDA - A product marketed under an approved New Drug Application
Lotensin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Lotensin global name
benazepril hydrochloride
Lotensin global name
Benazepril Hydrochloride
Start - Stop data
START DATA:
1991-Jun-21
Start - Stop data
STOP DATA
not occurred

Lotensin for patients

Pregnancy

Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ACE inhibitors, and they should also be told that these consequences do not appear to have resulted from intrauterine ACE inhibitor exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.

Angioedema

Angioedema, including laryngeal edema, can occur at any time with treatment with ACE inhibitors. Patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, eyes, lips, or tongue, or difficulty in breathing) and to take no more drug until they have consulted with the prescribing physician.

Symptomatic Hypotension

Patients should be cautioned that lightheadedness can occur, especially during the first days of therapy, and it should be reported to the prescribing physician. Patients should be told that if syncope occurs, Lotensin should be discontinued until the prescribing physician has been consulted.

All patients should be cautioned that inadequate fluid intake or excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.

Hyperkalemia

Patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.

Neutropenia

Patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia.

Lotensin Interactions

Diuretics

Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Lotensin. The possibility of hypotensive effects with Lotensin can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with Lotensin. If this is not possible, the starting dose should be reduced.

Potassium Supplements and Potassium-Sparing Diuretics

Lotensin can attenuate potassium loss caused by thiazide diuretics. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Therefore, if concomitant use of such agents is indicated, they should be given with caution, and the patient’s serum potassium should be monitored frequently.

Oral Anticoagulants

Interaction studies with warfarin and acenocoumarol failed to identify any clinically important effects on the serum concentrations or clinical effects of these anticoagulants.

Lithium

Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium. These drugs should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.

Other

No clinically important pharmacokinetic interactions occurred when Lotensin was administered concomitantly with hydrochlorothiazide, chlorthalidone, furosemide, digoxin, propranolol, atenolol, naproxen, or cimetidine.

Lotensin has been used concomitantly with beta-adrenergic-blocking agents, calcium-channel-blocking agents, diuretics, digoxin, and hydralazine, without evidence of clinically important adverse interactions. Lotensin, like other ACE inhibitors, has had less than additive effects with beta-adrenergic blockers, presumably because both drugs lower blood pressure by inhibiting parts of the renin-angiotensin system.

 

 

Lotensin Contraindications

Lotensin is contraindicated in patients who are hypersensitive to this product or to any other ACE inhibitor.

Manufacturers name:

  • Physicians Total Care, Inc
  • PD-Rx Pharmaceuticals, Inc
  • Validus Pharmaceuticals LLC
  • Novartis Pharmaceuticals Corporation

Generic name, Overdose, Half Life Lotensin, Food Interactions, Chemical, etc..

Lotensin see also FDA report Barrenwort

Blood Pressure
Brand Names containing Benazepril