Lyrica Indication:

For management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.

Lyrica Mechanism Of Action:

Lyrica binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalinís antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function.

Lyrica Drug Interactions:

Pioglitazone Increased risk of edema
Rosiglitazone Increased risk of edema

Lyrica Food Interactions:

Not Available

Lyrica Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Illicit; Approved

Absorption:

Well absorbed after oral administration.

Toxicity (Overdose):

Not Available

Protein Binding:

Not Available

Biotransformation:

Negligible

Half Life:

~6 hours

Dosage Forms of Lyrica:

Capsule Oral

Chemical IUPAC Name:

(3S)-3-(aminomethyl)-5-methylhexanoic acid

Organisms Affected:

Humans and other mammals

Lyrica to general, pharmacology

General, pharmacology..
Anticonvulsants