Macrodantin

A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression. .
[PubChem].

Medicinal name:
  • Nitrofurantoin 100 MG Oral Capsule [Macrodantin]
  • Nitrofurantoin 50 MG Oral Capsule [Macrodantin]
  • Nitrofurantoin 25 MG Oral Capsule [Macrodantin]

Macrodantin - Pharmacology:

Macrodantin inhibits bacterial acetyl-coenzyme A, interfering with the organism's carbohydrate metabolism. The drug also can disrupt bacterial cell wall formation.

Macrodantin mini report

Macrodantin NDA
NDA - A product marketed under an approved New Drug Application
Macrodantin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Macrodantin global name
Nitrofurantoin macrocrystals
Start - Stop data
START DATA:
2010-Sep-27
Start - Stop data
STOP DATA
not occurred

Macrodantin for patients

Patients should be advised to take Macrobid with food (ideally breakfast and dinner) to further enhance tolerance and improve drug absorption. Patients should be instructed to complete the full course of therapy; however, they should be advised to contact their physician if any unusual symptoms occur during therapy.

Patients should be advised not to use antacid preparations containing magnesium trisilicate while taking Macrobid.

Patients should be counseled that antibacterial drugs including Macrobid should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Macrobid is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Macrobid or other antibacterial drugs in the future.

Macrodantin Interactions

Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.

Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.

Drug/Laboratory Test Interactions

As a result of the presence of nitrofurantoin, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions but not with the glucose enzymatic test.

Macrodantin Contraindications

Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug.

Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38-42 weeks gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age.

Macrobid is also contraindicated in those patients with known hypersensitivity to nitrofurantoin.

Manufacturers name:

  • Almatica Pharma Inc
  • Procter & Gamble Pharmaceuticals

Macrodantin tags categories:

Generic name, Overdose, Half Life Macrodantin, Food Interactions, Chemical, etc..

Macrodantin see also FDA report

Antibiotics