Malarone

A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. .
[PubChem].


Most likely, Malarone - a mixture:
Malarone (Atovaquone + Proguanil Hydrochloride)

Medicinal name:
  • Atovaquone 62.5 MG / proguanil hydrochloride 25 MG Oral Tablet [Malarone]
  • Atovaquone 250 MG / proguanil hydrochloride 100 MG Oral Tablet [Malarone]

Malarone - Pharmacology:

Malarone is a hydroxy- 1, 4- naphthoquinone, an analog of ubiquinone, with antipneumocystis activity. The mechanism of action against Pneumocystis carinii has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III). Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis. Malarone also has been shown to have good in vitro activity against Toxoplasma gondii.

Malarone mini report

Malarone NDA
NDA - A product marketed under an approved New Drug Application
Malarone TABLET, FILM COATED
TABLET, FILM COATED
Malarone HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Malarone global name
atovaquone and proguanil hydrochloride
Start - Stop data
START DATA:
2000-Jul-26
Start - Stop data
STOP DATA
not occurred

Malarone for patients

The importance of taking the prescribed dose of MEPRON should be stressed. Patients should be instructed to take their daily doses of MEPRON with meals, as the presence of food will significantly improve the absorption of the drug.

Malarone Interactions

Malarone is highly bound to plasma protein (99.9%). Therefore, caution should be used when administering MEPRON concurrently with other highly plasma protein- bound drugs with narrow therapeutic indices, as competition for binding sites may occur. The extent of plasma protein binding of atovaquone in human plasma is not affected by the presence of therapeutic concentrations of phenytoin (15 mcg/ mL), nor is the binding of phenytoin affected by the presence of atovaquone.

Rifampin: Coadministration of rifampin and MEPRON Suspension results in a significant decrease in average steady- state plasma atovaquone concentrations. Alternatives to rifampin should be considered during the course of PCP treatment with MEPRON.

Rifabutin, another rifamycin, is structurally similar to rifampin and may possibly have some of the same drug interactions as rifampin. No interaction trials have been conducted with MEPRON and rifabutin.

Drug/ Laboratory Test Interactions: It is not known if MEPRON interferes with clinical laboratory test or assay results.

Malarone Contraindications

MEPRON Suspension is contraindicated for patients who develop or have a history of potentially life-threatening allergic reactions to any of the components of the formulation.

Manufacturers name:

  • GlaxoSmithKline LLC
  • PD-Rx Pharmaceuticals, Inc

Generic name, Overdose, Half Life Malarone, Food Interactions, Chemical, etc..

Malarone see also FDA report

Brand Names containing Atovaquone