Marcaine

A widely used local anesthetic agent. .
[PubChem].


Most likely, Marcaine - a mixture:
Marcaine E (Bupivacaine Hydrochloride + Epinephrine Bitartrate)

Marcaine - Pharmacology:

Local anesthetics such as bupivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone. The analgesic effects of Bupivicaine are thought to be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.

Marcaine mini report

Marcaine ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Marcaine NDA
NDA - A product marketed under an approved New Drug Application
Marcaine SUBCUTANEOUS
SUBCUTANEOUS
Marcaine EPIDURAL
EPIDURAL
Marcaine EPIDURAL; INFILTRATION
EPIDURAL; INFILTRATION
Marcaine EPIDURAL; RETROBULBAR
EPIDURAL; RETROBULBAR
Marcaine INFILTRATION
INFILTRATION
Marcaine INJECTION, SOLUTION
INJECTION, SOLUTION
Marcaine HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Marcaine global name
bupivacaine hydrochloride and epinephrine bitartrate
Marcaine global name
Bupivacaine Hydrochloride
Marcaine global name
BUPIVACAINE HYDROCHLORIDE
Start - Stop data
START DATA:
2013-Jun-01
Start - Stop data
STOP DATA
not occurred

Marcaine for patients

When appropriate, patients should be informed in advance that they may experience temporary loss of sensation and motor activity, usually in the lower half of the body following proper administration of caudal or lumbar epidural anesthesia. Also, when appropriate, the physician should discuss other information including adverse reactions in the Sensorcaine package insert.

Marcaine Interactions

The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. Concurrent use of these agents should generally be avoided. In situations in which concurrent therapy is necessary, careful patient monitoring is essential.

Concurrent administration of vasopressor drugs and of ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.

Marcaine Contraindications

Sensorcaine (bupivacaine HCl) is contraindicated in obstetrical paracervical block anesthesia. Its use by this technique has resulted in fetal bradycardia and death.

Sensorcaine is contraindicated in patients with a known hypersensitivity to it or to any local anesthetic agent of the amide type or to other components of bupivacaine solutions.

Generic name, Overdose, Half Life Marcaine, Food Interactions, Chemical, etc..

Marcaine see also

Brand Names containing Bupivacaine