Maxalt Indication:

For treatment of acute migraine attacks.

Maxalt Mechanism Of Action:

Maxalt binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction.

Maxalt Drug Interactions:

Not Available

Maxalt Food Interactions:

Not Available

Maxalt Generic Name:

Synonyms:

  • Rizatriptan benzoat
  • Rizatriptan benzoate
  • Risatriptan
  • MK 462 Free Base

Drug Type:

Small Molecule; Approved

Absorption:

Rapid following oral administration. Bioavailability is 45%. Food has no effect on the bioavailability of rizatriptan. However, administering rizatriptan with food will delay by 1 hour the time to reach peak plasma concentration. The rate of absorption is not affected by the presence of a migraine attack.

Toxicity (Overdose):

Symptoms of overdose include dizziness, fainting, heart and blood vessel problems, high blood pressure, loss of bowel and bladder control, slow heartbeat, and vomiting.

Protein Binding:

14%

Biotransformation:

Rizatriptan is metabolized by monoamine oxidase A isoenzyme (MAO-A) to an inactive indole acetic acid metabolite. In addition, several other inactive metabolites are formed. An active metabolite, N-monodesmethyl-rizatriptan, with pharmacological activity similar to that of the parent compound has been identified in small concentrations (14%) in the plasma.

Half Life:

2-3 hours

Dosage Forms of Maxalt:

Tablet Oral
Wafer Oral

Chemical IUPAC Name:

N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

Organisms Affected:

Humans and other mammals

Maxalt to general, pharmacology

General, pharmacology..
Pain Relief