Metasol TK 100 - General Information:2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Other Brand Names containing Thiabendazole
Metasol TK 100 - Pharmacology:
The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Metasol TK 100 for patients
Because CNS side effects may occur quite frequently, activities requiring mental alertness should be avoided.
Metasol TK 100 Interactions
Thiabendazole may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the dosage of such compounds. Such concomitant use should be administered under careful medical supervision.
Metasol TK 100 Contraindications
Hypersensitivity to this product.
Thiabendazole is contraindicated as prophylactic treatment for pinworm infestation.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..