Mexitil Indication:

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexitil Mechanism Of Action:

Mexitil, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. Mexitil decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals

Mexitil Drug Interactions:

Aminophylline Mexitil increases the effect and toxicity of theophylline
Dyphylline Mexitil increases the effect and toxicity of theophylline
Oxtriphylline Mexitil increases the effect and toxicity of theophylline
Theophylline Mexitil increases the effect and toxicity of theophylline
Ethotoin The hydantoin decreases the effect of mexiletine
Fosphenytoin The hydantoin decreases the effect of mexiletine
Mephenytoin The hydantoin decreases the effect of mexiletine
Phenytoin The hydantoin decreases the effect of mexiletine
Fluvoxamine Fluvoxamine increases the effect and toxicity of mexiletine
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Rifampin Rifampin decreases the effect of mexiletine
Propafenone Propafenone increases the effects/toxicity of mexiletine

Mexitil Food Interactions:

Not Available

Mexitil Generic Name:

Synonyms:

  • Mexiletina [INN-Spanish]
  • Mexiletine HCL
  • Mexiletinum [INN-Latin]
  • Mexilitine

Drug Type:

Small Molecule; Approved

Absorption:

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Toxicity (Overdose):

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Protein Binding:

50-60%

Biotransformation:

Primarily hepatic (85%) via CYP2D6 and CYP1A2 (primarily CYP2D6).

Half Life:

10-12 hours

Dosage Forms of Mexitil:

Capsule Oral

Chemical IUPAC Name:

1-(2,6-dimethylphenoxy)propan-2-amine

Organisms Affected:

Humans and other mammals

Mexitil to general, pharmacology

General, pharmacology..
Heart & Cholesterol