Mircette Indication:

For the prevention of pregnancy in women who elect to use this product as a method of contraception.

Mircette Mechanism Of Action:

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Mircette Drug Interactions:

Not Available

Mircette Food Interactions:

Not Available

Mircette Generic Name:

Synonyms:

  • Desogestrelum [Inn-Latin]

Drug Type:

Small Molecule; Approved

Absorption:

Following oral administration, the relative bioavailability of desogestrel compared to a solution, as measured by serum levels of etonogestrel, is approximately 100%.

Toxicity (Overdose):

Symptoms of overdose include nausea and vaginal bleeding.

Protein Binding:

98.3%

Biotransformation:

Desogestrel is rapidly and completely metabolized by hydroxylation in the intestinal mucosa and on first pass through the liver to etonogestrel. Other metabolites (i.e., 3a-OH-desogestrel, 3b-OH-desogestrel, and 3a-OH-5a-H-desogestrel) with no pharmacologic actions also have been identified and these metabolites may undergo glucuronide and sulfate conjugation.

Half Life:

27.8±7.2 hours

Dosage Forms of Mircette:

Tablet Oral

Chemical IUPAC Name:

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol

Organisms Affected:

Humans and other mammals

Mircette to general, pharmacology

General, pharmacology..