Motrin Indication:

For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia

Motrin Mechanism Of Action:

The exact mechanisms of action of Motrin is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Motrin Drug Interactions:

Acebutolol Risk of inhibition of renal prostaglandins
Atenolol Risk of inhibition of renal prostaglandins
Betaxolol Risk of inhibition of renal prostaglandins
Bevantolol Risk of inhibition of renal prostaglandins
Bisoprolol Risk of inhibition of renal prostaglandins
Carteolol Risk of inhibition of renal prostaglandins
Carvedilol Risk of inhibition of renal prostaglandins
Esmolol Risk of inhibition of renal prostaglandins
Labetalol Risk of inhibition of renal prostaglandins
Nadolol Risk of inhibition of renal prostaglandins
Metoprolol Risk of inhibition of renal prostaglandins
Oxprenolol Risk of inhibition of renal prostaglandins
Penbutolol Risk of inhibition of renal prostaglandins
Pindolol Risk of inhibition of renal prostaglandins
Practolol Risk of inhibition of renal prostaglandins
Propranolol Risk of inhibition of renal prostaglandins
Sotalol Risk of inhibition of renal prostaglandins
Timolol Risk of inhibition of renal prostaglandins
Warfarin The NSAID increases the anticoagulant effect
Acenocoumarol The NSAID increases the anticoagulant effect
Dicumarol The NSAID increases the anticoagulant effect
Anisindione The NSAID increases the anticoagulant effect
Ethacrynic acid The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic
Furosemide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic
Torasemide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic
Bumetanide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic
Aspirin Motrin reduces ASA cardioprotective effects
Methotrexate The NSAID increases the effect and toxicity of methotrexate
Alendronate Increased risk of gastric toxicity
Cyclosporine Monitor for nephrotoxicity
Lithium The NSAID increases serum levels of lithium

Motrin Food Interactions:

Avoid alcohol.
Take with food to reduce irritation.

Motrin Generic Name:

Synonyms:

  • P-Isobutylhydratropic Acid
  • Para-Isobutylhydratropic Acid
  • Ibuprophen

Drug Type:

Small Molecule; Approved

Absorption:

rapidly absorbed

Toxicity (Overdose):

Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)

Protein Binding:

99%

Biotransformation:

Hepatic

Half Life:

1.8-2.0 hours

Dosage Forms of Motrin:

Tablet Oral
Tablet, chewable Oral
Suspension Oral
Capsule Oral

Chemical IUPAC Name:

2-[4-(2-methylpropyl)phenyl]propanoic acid

Organisms Affected:

Humans and other mammals

Motrin to general, pharmacology

General, pharmacology..
Arthritis