Mycelex-G Indication:

For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.

Mycelex-G Mechanism Of Action:

Mycelex-G interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Mycelex-G may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.

Mycelex-G Drug Interactions:

Not Available

Mycelex-G Food Interactions:

Not Available

Mycelex-G Generic Name:

Synonyms:

  • Clotrimazol
  • Chlotrimazole

Drug Type:

Small Molecule; Approved

Absorption:

Poorly and erratically absorbed orally, minimal vaginal or topical absorption.

Toxicity (Overdose):

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.

Protein Binding:

90%

Biotransformation:

Hepatic (metabolized to inactive metabolites)

Half Life:

2 hours

Dosage Forms of Mycelex-G:

Cream Topical
Cream Intravaginal

Chemical IUPAC Name:

1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole

Organisms Affected:

Yeast and other fungi

Mycelex-G to general, pharmacology

General, pharmacology..