Nadide

Nadide is the reduced form of NAD+, and NAD+ is the oxidized form of Nadide, A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.(Dorland, 27th ed)

Nadide - Pharmacology:

Nadide is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, Nadide is produced in the cytosol. The mitochondrial membrane is impermeable to Nadide, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial Nadide pools. However, cytoplasmic Nadide can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from Nadide in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.

Nadide Interactions

Data is temporarily not available

Nadide Contraindications

None known.

Nadide tags categories:

Generic name, Overdose, Half Life Nadide, Food Interactions, Chemical, etc..

Nadide see also