Nexium Indication:

For the treatment of acid-reflux disorders (GERD) and peptic ulcer disease

Nexium Mechanism Of Action:

Nexium is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Nexium blocks the final step in acid production, thus reducing gastric acidity.

Nexium Drug Interactions:

Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Enoxacin The agent decreases the absorption of enoxacin
Indinavir Omeprazole decreases the absorption of indinavir
Itraconazole The proton pump inhibitor decreases the absorption of imidazole
Ketoconazole The proton pump inhibitor decreases the absorption of imidazole

Nexium Food Interactions:

Take without regard to meals.

Nexium Generic Name:

Synonyms:

  • Esomeprazole Sodium
  • Esomperazole

Drug Type:

Small Molecule; Approved

Absorption:

90%

Toxicity (Overdose):

Blurred vision, confusion, drowsiness, dry mouthflushingheadache, nausea, rapid heartbeat, sweating

Protein Binding:

97%

Biotransformation:

Hepatic

Half Life:

1-1.5 hours

Dosage Forms of Nexium:

Capsule, delayed release Oral
Tablet, delayed release Oral
Capsule Oral

Chemical IUPAC Name:

6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

Organisms Affected:

Humans and other mammals

Nexium to general, pharmacology

General, pharmacology..