Nicovel - General Information:

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has pellagra-curative, vasodilating, and antilipemic properties. [PubChem]

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Nicovel - Pharmacology:

Nicovel binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic acid phosphoribosyltransferase, Nicotinate N-methyltransferase and the Nicovel receptor. Nicovel is the precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are vital cofactors for dozens of enzymes. The mechanism by which niacin exerts its lipid lowering effects is not entirely understood, but may involve several actions, including a decrease in esterification of hepatic triglycerides. Nicovel treatment also decreases the serum levels of apolipoprotein B-100 (apo B), the major protein component of the VLDL (very low-density lipoprotein) and LDL fractions.

Nicovel for patients

Patient Information:

Diabetic patient and patient with liver problems or peptic ulcer should take
niacin with caution and should monitor liver funtion test, blood glucose
frequently.

Niacin should also used with caution in patients with elevated uric acid levels,
gout, unstable angina, and acute phase of myocardial infarction.

Niacin may interact with some antihypertensive drugs, aspirin, and alcohol. Patient should
check with a health professional before start taking niacin or start a new medication.

Nicovel Interactions

Interactions for Vitamin B3 (Niacin):

Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.

Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear.

Other: Concomitant alcohol or hot drinks may increase the side effects of flushing and pruritus and should be avoided at the time of drug ingestion.

Nicovel Contraindications

Contraindications for Vitamin B3 (Niacin):

Nicotinic acid is contraindicated in patients with a known hypersensitivity to any component of this medication; significant or unexplained hepatic dysfunction; active peptic ulcer disease; or arterial bleeding.

Nicovel more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..
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