Oflox

An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. .
[PubChem].

Medicinal name:
  • Ofloxacin 400 MG Oral Tablet
  • Ofloxacin 300 MG Oral Tablet
  • Ofloxacin 200 MG Oral Tablet

Oflox - Pharmacology:

The mechanism of action of rimantadine is not fully understood. Oflox appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. Genetic studies suggest that a virus protein specified by the virion M2 gene plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine.

Oflox Interactions

Cimetidine: The effects of chronic cimetidine use on the metabolism of rimantadine are not known. When a single 100 mg dose of rimantadine HCl was administered one hour after the initiation of Cimetidine (300 mg four times a day), the apparent total rimantadine clearance of this single dose in normal healthy adults was reduced by 18% (compared to the apparent total rimantadine clearance in the same subjects in the absence of cimetidine).

Acetaminophen: Oflox HCl, 100 mg, was given twice daily for 13 days to 12 healthy volunteers. On day 11, acetaminophen (650 mg four times daily) was started and continued for 8 days. The pharmacokinetics of rimantadine were assessed on days 11 and 13. Coadministration with acetaminophen reduced the peak concentration and AUC values for rimantadine by approximately 11%.

Aspirin: Oflox HCl, 100 mg, was given twice daily fro 13 days to 12 healthy volunteers. On day 11, aspirin (650 mg, four times daily) was started and continued for 8 days. The pharmacokinetics of rimantadine were assessed on days 11 and 13. Peak plasma concentrations and AUC of rimantadine were reduced approximately 10% in the presence of aspirin.

Oflox Contraindications

Oflox HCl is contraindicated in patients with known hypersensitivity to drugs of the adamantine class, including rimantadine and amantadine.

Manufacturers name:

  • PD-Rx Pharmaceuticals, Inc
  • Dr Reddys Laboratories Limited
  • Cadila Pharmaceuticals Limited
  • Teva Pharmaceuticals USA Inc
  • REMEDYREPACK INC

Generic name, Overdose, Half Life Oflox, Food Interactions, Chemical, etc..

Oflox see also

Brand Names containing Rimantadine