Oncovin

Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)

Oncovin - Pharmacology:

The antitumor activity of Oncovin is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Oncovin may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.

Oncovin for patients

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Oncovin.html

Oncovin Interactions

The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. Dosage adjustment should be based on serial blood level monitoring. The contribution of vincristine sulfate to this interaction is not certain. The interaction may result from reduced absorption of phenytoin and an increase in the rate of its metabolism and elimination.

Oncovin Contraindications

Patients with the demyelinating form of Charcot-Marie-Tooth syndrome would not be given vincristine sulfate injection.

Generic name, Overdose, Half Life Oncovin, Food Interactions, Chemical, etc..

Oncovin see also

Brand Names containing Vincristine