Opana - General Information:

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

Manufacturers name:

  • STAT RX USA LLC
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Endo Pharmaceuticals Inc
  • Endo Pharmaceuticals
  • Bryant Ranch Prepack
  • Rebel Distributors Corp
  • Lake Erie Medical DBA Quality Care Products LLC
  • St Marys Medical Park Pharmacy

Medicinal name:

  • 12 HR Oxymorphone Hydrochloride 10 MG Extended Release Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 40 MG Extended Release Oral Tablet [Opana]
  • Oxymorphone Hydrochloride 10 MG Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 15 MG Extended Release Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 20 MG Extended Release Oral Tablet [Opana]
  • Oxymorphone Hydrochloride 5 MG Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 5 MG Extended Release Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 30 MG Extended Release Oral Tablet [Opana]
  • 12 HR Oxymorphone Hydrochloride 7.5 MG Extended Release Oral Tablet [Opana]

Other Brand Names containing Oxymorphone

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Opana - Pharmacology:

Opana interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve.

Opana for patients

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Opana Interactions

The concomitant use of other CNS depressants including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, tricyclic antidepressants, monoamine oxidase (MAO) inhibitors, and alcohol may produce additive CNS depressant effects. When such combined therapy is contemplated, the dose of one or both agents should be reduced.

Anticholinergics or other medications with anticholinergic activity when used concurrently with opioid analgesics may result in increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus.

It has been reported that the incidence of bradycardia was increased when oxymorphone was combined with propofol for induction of anesthesia.

In addition, CNS toxicity has been reported (confusion, disorientation, respiratory depression, apnea, seizures) following coadministration of cimetidine with opioid analgesics; no clear-cut cause and effect relationship was established.

Opana Contraindications

NUMORPHAN should not be administered to patients who are hypersensitive to oxymorphone hydrochloride or to any of the other ingredients in NUMORPHAN, or hypersensitive to morphine analogs.

NUMORPHAN should not be administered to individuals during an acute asthmatic attack or to patients with severe respiratory depression, upper airway obstruction, or any patient who has or is suspected of having a paralytic ileus. NUMORPHAN should not be used in the treatment of pulmonary edema secondary to a chemical respiratory irritant. Opioid analgesics cause pooling of blood in the extremities by decreasing peripheral vascular resistance. This effect results in decreases in venous return, cardiac work, and pulmonary venous pressure, and blood is shifted from the central to peripheral circulation which would not be beneficial in the treatment of pulmonary edema secondary to a chemical respiratory irritant.

Opana more info

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