PDP

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)

PDP - Pharmacology:

PDP is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. PDP may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. PDP, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.

PDP for patients

The patient should be fully aware of the importance of continuing all of his antihypertensive medications and of the nature of symptoms that would suggest fluid overload. A patient brochure has been prepared and is included with each minoxidil package.

PDP tablets contain minoxidil, a medicine for the treatment of high blood pressure in the patient who has not been controlled or is experiencing unacceptable side effects with other medications. It must usually be taken with other medicines.

Be absolutely sure to take all of your medicines for high blood pressure according to your doctors instructions. Do not stop taking minoxidil unless your doctor tells you to. Do not give any of your medicine to other people.

It is important that you look for the warning signals of certain undesired effects of minoxidil. Call your doctor if they occur. Your doctor will need to see you regularly while you are taking minoxidil. Be sure to keep all your appointments or to arrange for new ones if you must miss one.

Do not hesitate to call your doctor if any discomforts or problems occur.

The information here is intended to help you take minoxidil properly. It does not tell you all there is to know about minoxidil. There is a more technical leaflet that you may request from the pharmacist; you may need your doctors help in understanding parts of that leaflet.

What is PDP?

PDP tablets contain minoxidil which is a drug for lowering the blood pressure. It works by relaxing and enlarging certain small blood vessels so that blood flows through them more easily.

Why lower blood pressure?

Your doctor has prescribed minoxidil to lower your blood pressure and protect vital parts of your body. Uncontrolled blood pressure can cause stroke, heart failure, blindness, kidney failure and heart attacks.

Most people with high blood pressure need to take medicines to treat it for their whole lives.

Who should not take PDP?

There are many people with high blood pressure, but most of them do not need minoxidil. PDP is used ONLY when your doctor decides that:

1. your high blood pressure is severe;

2. your high blood pressure is causing symptoms or damage to vital organs; and

3. other medicines did not work well enough or had very disturbing side effects.

PDP should be taken only when a doctor prescribes it. Never give any of your minoxidil tablets, or any other high blood pressure medicine, to a friend or relative.

Pregnancy: In some cases doctors may prescribe minoxidil for women who are pregnant or who are planning to have children. However, its safe use in pregnancy has not been established. Laboratory animals had a reduced ability to become pregnant and a reduced survival of offspring while taking minoxidil, if you are pregnant or are planning to become pregnant, be sure to tell your doctor.

How to take minoxidil.

Usually, your doctor will prescribe two other medicines along with minoxidil. These will help lower blood pressure and will help prevent undesired effects of minoxidil.

Often, when a medicine like minoxidil lowers blood pressure your body tries to return the blood pressure to the original higher level. It does this by holding on to water and salt (so there will be more fluid to pump) and by making your heart beat faster, To prevent this, your doctor will usually prescribe a water tablet to remove the extra salt and water from your body (a diuretic dye-u-RET-tic) and another medicine to slow your heart beat.

You must follow your doctors instructions exactly, taking all the prescribed medicines, in the right amounts, each day. These medicines will help keep your blood pressure down. The water tablet and heart beat medicine will help prevent the undesired effects of minoxidil.

PDP tablets come in two strengths (2 1/2 milligrams and 10 milligrams) that are marked on each tablet. Pay close attention to the tablet markings to be sure you are taking the correct strength. Your doctor may prescribe half a tablet, the tablets are scored (partly cut on one side) so that you can easily break them.

When you first start taking minoxidil, your doctor may need to see you often in order to adjust your dosage. Take all your medicine according to the schedule prescribed by your doctor. Do not skip any doses. If you should forget a dose of minoxidil, wait until it is time for your next dose, then continue with your regular schedule, Remember: do not stop taking minoxidil, or any other, high blood pressure medicines, without checking with your doctor. Make sure that any doctor treating or examining you knows that you are taking high blood pressure medicines, including minoxidil.

WARNING SIGNALS

Even if you take all your medicines correctly, minoxidil tablets may cause undesired effects. Some of these are serious and you should be on the lookout for them. If any of the following warning signals occur, you must call your doctor immediately:

1. Increase in heart rate - You should measure your heart rate by counting your pulse rate while you are resting. If you have an increase of 20 beats or more a minute over your normal pulse, contact your doctor immediately. if you do not know how to take your pulse rate, ask your doctor. Also ask your doctor how often to check your pulse.

2. Rapid weight gain of more than 5 pounds - You should weigh yourself daily. If you quickly gain five or more pounds or if there is any swelling or puffiness in the face, hands, ankles, or stomach area, this could be a sign that you are retaining body fluids. Your doctor may have to change your drugs or change the dose of your drugs. You may also need to reduce the amount of salt you eat. A smaller weight gain (2 to 3 pounds) often occurs when treatment is started. You may lose this extra weight with continued treatment.

3. Increased difficulty in breathing, especially when lying down. This too may be due to an increase of body fluids. It can also happen because your high blood pressure is getting worse. In either case, you might require treatment with other medicines.

4. New or worsening of pain in the chest, arm, or shoulder or signs of severe indigestion - These could be signs of serious heart problems.

5. Dizziness, lightheadedness or fainting - These can be signs of high blood pressure or they may be side effect from one of the medicine. Your doctor may need to change or adjust the dosage of the medicines you are taking.

OTHER UNDESIRED EFFECTS

PDP tablets can cause other undesired effects such as nausea and/or vomiting that are annoying but not dangerous. Do not stop taking the drug because of these other undesired effects without talking to your doctor.

Hair growth: About 8 out of every 10 patients who have taken minoxidil noticed that fine body hair grew darker or longer on certain parts of the body. This happened about 3 to 6 weeks after beginning treatment. The hair may first be noticed on the forehead and temples, between the eyebrows or on the upper part of the cheeks. Later, hair may grow on the back, arms, legs, or scalp. Although hair growth may not be noticeable to some patients, it often is bothersome in women and children. Unwanted hair can be controlled with a hair remover or by shaving. The extra hair is not permanent, it disappears within 1 to 6 months of stopping minoxidil.Nevertheless, you should not stop taking minoxidil without first talking to your doctor.

A few patients have developed a rash or breast tenderness while taking minoxidil tablets, but this is unusual.

Store at controlled room temperature 15°-30°C (59°-86°F).

CAUTION: Federal law prohibits dispensing without prescription.

PDP Interactions

Interaction with Guanethidine: Although minoxidil does not itself cause orthostatic hypotension, its administration to patients already receiving guanethidine can result in profound orthostatic effects. If at all possible guanethidine should be discontinued well before minoxidil is begun. Where this is not possible, minoxidil therapy should be started in the hospital and the patient should remain institutionalized until severe orthostatic effects are no longer present or the patient has learned to avoid activities that provoke them.

PDP Contraindications

PDP tablets are contraindicated in pheochromocytoma, because it may stimulate secretion of catecholamines from the tumor through its antihypertensive action. PDP is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Generic name, Overdose, Half Life PDP, Food Interactions, Chemical, etc..

PDP see also Saw Palmetto

Mens-health