PRECEDEX

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. .
[PubChem].

PRECEDEX - Pharmacology:

PRECEDEX is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals. Avtivation of the postsynaptic alpha-2 adrenoceptors inhibits the sympathetic activity decreases blood pressure and heart rate.

PRECEDEX mini report

PRECEDEX NDA
NDA - A product marketed under an approved New Drug Application
PRECEDEX INTRAVENOUS
INTRAVENOUS
PRECEDEX INJECTION, SOLUTION
INJECTION, SOLUTION
PRECEDEX INJECTION, SOLUTION, CONCENTRATE
INJECTION, SOLUTION, CONCENTRATE
PRECEDEX HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
PRECEDEX global name
DEXMEDETOMIDINE HYDROCHLORIDE
Start - Stop data
START DATA:
2013-Apr-08
Start - Stop data
STOP DATA
not occurred

PRECEDEX for patients

PRECEDEX should be administered only by persons skilled in the management of patients in the intensive care setting. Due to the known pharmacological effects of PRECEDEX, patients should be continuously monitored while receiving PRECEDEX.

Reports of hypotension and bradycardia have been associated with Precedex infusion. If medical intervention is required, treatment may include decreasing or stopping the infusion of Precedex, increasing the rate of IV fluid administration, elevation of the lower extremities, and use of pressor agents.

PRECEDEX Interactions

General

In vitro studies in human liver microsomes demonstrated no evidence of cytochrome P450-mediated drug interactions that are likely to be of clinical relevance.

Anesthetics/Sedatives/Hypnotics/Opioids

Co-administration of PRECEDEX with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects. Specific studies have confirmed these effects with sevoflurane, isoflurane, propofol, alfentanil, and midazolam. No pharmacokinetic interactions between dexmedetomidine and isoflurane, propofol, alfentanil, and midazolam have been demonstrated. However, due to possible pharmacodynamic interactions, when co-administered with PRECEDEX, a reduction in dosage of PRECEDEX on the concomitant anesthetic, sedative, hypnotic or opioid may be required.

Neuromuscular Blockers

In one study of 10 healthy volunteers, administration of PRECEDEX for 45 minutes at a plasma concentration of 1 (one) ng/mL resulted in no clinically meaningful increases in the magnitude or neuromuscular blockade associated with rocuronium administration.

PRECEDEX Contraindications

No specific information available.

 

Generic name, Overdose, Half Life PRECEDEX, Food Interactions, Chemical, etc..

PRECEDEX see also FDA report