Pamelor Indication:

For the treatment of depression.

Pamelor Mechanism Of Action:

It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.

Pamelor Drug Interactions:

Altretamine Risk of hypotension
Atazanavir Atazanavir increases the effect and toxicity of tricyclics
Carbamazepine The tricyclic increases the effect of carbamazepine
Cimetidine Cimetidine increases the effect of tricyclic agent
Clonidine The tricyclic decreases the effect of clonidine
Duloxetine Possible increase in the levels of this agent when used with duloxetine
Fluoxetine Fluoxetine increases the effect and toxicity of tricyclics
Fluvoxamine Fluvoxamine increases the effect and toxicity of tricyclics
Guanethidine The tricyclic decreases the effect of guanethidine
Terbinafine Terbinafine increases the effect and toxicity of the tricyclic
Ritonavir Ritonavir increases the effect and toxicity of the tricyclics
Tranylcypromine Possibility of severe adverse effects
Rasagiline Possibility of severe adverse effects
Phenelzine Possibility of severe adverse effects
Isocarboxazid Possibility of severe adverse effects
Cisapride Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Dihydroquinidine barbiturate Quinidine increases the effect of tricyclic agent
Quinidine Quinidine increases the effect of tricyclic agent
Quinidine barbiturate Quinidine increases the effect of tricyclic agent
Dobutamine The tricyclic increases the sympathomimetic effect
Dopamine The tricyclic increases the sympathomimetic effect
Ephedra The tricyclic increases the sympathomimetic effect
Ephedrine The tricyclic increases the sympathomimetic effect
Epinephrine The tricyclic increases the sympathomimetic effect
Fenoterol The tricyclic increases the sympathomimetic effect
Isoproterenol The tricyclic increases the sympathomimetic effect
Mephentermine The tricyclic increases the sympathomimetic effect
Metaraminol The tricyclic increases the sympathomimetic effect
Methoxamine The tricyclic increases the sympathomimetic effect
Norepinephrine The tricyclic increases the sympathomimetic effect
Orciprenaline The tricyclic increases the sympathomimetic effect
Phenylephrine The tricyclic increases the sympathomimetic effect
Phenylpropanolamine The tricyclic increases the sympathomimetic effect
Pseudoephedrine The tricyclic increases the sympathomimetic effect
Pirbuterol The tricyclic increases the sympathomimetic effect
Procaterol The tricyclic increases the sympathomimetic effect
Salbutamol The tricyclic increases the sympathomimetic effect
Terbutaline The tricyclic increases the sympathomimetic effect
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Moclobemide Possible severe adverse reaction with this combination
Rivastigmine Possible antagonism of action
Sibutramine Increased risk of CNS adverse effects
Fluconazole The imidazole increases the effect and toxicity of the tricyclic
Ketoconazole The imidazole increases the effect and toxicity of the tricyclic
Rifabutin The rifamycin decreases the effect of tricyclics
Rifampin The rifamycin decreases the effect of tricyclics

Pamelor Food Interactions:

Avoid alcohol.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).

Pamelor Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

Well absorbed from the GI tract.

Toxicity (Overdose):

Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)

Protein Binding:

Highly protein-bound in plasma and tissues

Biotransformation:

Hepatic

Half Life:

16 and 90 hours

Dosage Forms of Pamelor:

Capsule Oral

Chemical IUPAC Name:

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Organisms Affected:

Humans and other mammals

Pamelor to general, pharmacology

General, pharmacology..