Pertofrane - General Information:

Tricyclic antidepressant similar in action and side effects to imipramine. It may produce excitation. [PubChem]

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Pertofrane - Pharmacology:

Pertofrane acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).

Pertofrane for patients

Protriptyline is used to treat the symptoms of mental depression in people who are under close medical supervision. It is particularly suitable for those who are inactive and withdrawn.

Protriptyline is a tricyclic antidepressants. Unlike the class of antidepressants known as monoamine oxidase (MAO) inhibitors, it does not act primarily through stimulation of the central nervous system. It tends to work more rapidly than some other tricyclic antidepressants. Improvement sometimes begins within a week.

If you are prone to anxiety or agitation, Protriptyline can make the problem worse. It can also exaggerate the symptoms of manic-depression and schizophrenia.

Protriptyline must never be taken with drugs classified as monoamine oxidase (MAO) inhibitors, such as the antidepressants Nardil and Parnate.

Protriptyline should be used with caution by people who have heart problems or a thyroid disorder.

Take precaution if you have a history of seizures, difficulty urinating, or glaucoma (high pressure in the eyes); or use alcohol excessively while taking Protriptyline.

Pertofrane Interactions

If Protriptyline is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Patient should check with doctor before combining Protriptyline with the following:

Antidepressants that boost serotonin, including Paxil, Prozac, and Zoloft
Antipsychotic medications such as Mellaril and chlopromazine
Barbiturates such as Nembutal and Seconal
Certain blood pressure medications such as guanethidine
Cimetidine (Tagamet)
Decongestants such as Sudafed
Drugs that quell spasms, such as Donnatal and Levsin
Epinephrine (EpiPen)
Flecainide (Tambocor)
Narcotic painkillers such as Percodan and Vicodin
Norepinephrine
Other antidepressants such as Elavil and Tofranil
Propafenone (Rythmol)
Quinidine
Tramadol (Ultram)
Tranquilizers and sleep aids such as Halcion, Valium, and Xanax

Protriptyline must never be combined with monoamine inhibitors such as Nardil and Parnate.

Pertofrane Contraindications

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