Placidyl - General Information:Placidyl is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia]
Other Brand Names containing Ethchlorvynol
Placidyl - Pharmacology:
Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Placidyl for patients
Avoid driving and other activities requiring alertness while taking this medication. Avoid alcohol and other depressants. Effects may take 2 nights before any benefits are noticed.
Dicumarol and warfarin may decrease hypoprothrombinemic effect. Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol.
Contraindicated in patients exhibiting hypersensitivity to this drug, in patients with severe pain, and in patients with porphyria.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..