Plendil General Information

A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. .

Manufacturers name:

  • AstraZeneca LP
  • Bryant Ranch Prepack

Medicinal name:

  • 24 HR Felodipine 2.5 MG Extended Release Oral Tablet [Plendil]
  • 24 HR Felodipine 10 MG Extended Release Oral Tablet [Plendil]
  • 24 HR Felodipine 5 MG Extended Release Oral Tablet [Plendil]

Plendil - Pharmacology:

Plendil competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.

Plendil for patients


Plendil is known as a histamine blocker or an H2-receptor blocker. It is used to treat
ulcers. Although this drug blocks histamine in the stomach, it cannot be used in place of
antihistamine used to treat runny noses and watery eyes. This drug works primarily in the
stomach and intestines. In most cases therapy is needed for 4-8 weeks to produce ulcer
healing. Some patients may need long term preventative therapy with lower doses taken at
bedtime. Plendil has no clinically significant drug interactions and few side effects.
The most common side effects reported include headache and abdominal pain. This medication
must be taken as prescribed for ulcers to heal. You may be asked to follow a certain diet
that will not aggravate your ulcer or cause a new one. If you choose to also take antacids,
take them two hours before or after taking this medication.

Plendil Interactions

No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. Plendil does not inhibit the cytochrome P-450-linked drug-metabolizing enzyme system; therefore, drug interactions mediated by inhibition of hepatic metabolism are not expected to occur. In patients given very high doses (3900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.

Plendil Contraindications

Plendil is contraindicated in patients with known hypersensitivity to the drug. Because cross sensitivity in this class of compounds has been observed, H2-receptor antagonists, including nizatidine, should not be administered to patients with a history of hypersensitivity to other H2-receptor antagonists.

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