Pre-Op - General Information:

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)

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Pre-Op - Pharmacology:

The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.

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Pre-Op Contraindications

Do not use on burned or denuded skin; as an occlusive dressing, wet pack or lotion; as vaginal pack or tampon, on mucous membranes or for routine prophylactic total body bathing.

Should not be used on persons hypersensitive to any of its components nor on persons who have demonstrated primary light sensitivity to halogenated phenol derivatives because of the possibility of cross-sensitivity to hexachlorophene.

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