Premarin Indication:

For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)

Premarin Mechanism Of Action:

Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.

Premarin Drug Interactions:

Amobarbital The enzyme inducer decreases the effect of hormones
Aprobarbital The enzyme inducer decreases the effect of hormones
Butabarbital The enzyme inducer decreases the effect of hormones
Butalbital The enzyme inducer decreases the effect of hormones
Butethal The enzyme inducer decreases the effect of hormones
Ethotoin The enzyme inducer decreases the effect of hormones
Fosphenytoin The enzyme inducer decreases the effect of hormones
Griseofulvin The enzyme inducer decreases the effect of hormones
Heptabarbital The enzyme inducer decreases the effect of hormones
Hexobarbital The enzyme inducer decreases the effect of hormones
Mephenytoin The enzyme inducer decreases the effect of hormones
Methohexital The enzyme inducer decreases the effect of hormones
Methylphenobarbital The enzyme inducer decreases the effect of hormones
Pentobarbital The enzyme inducer decreases the effect of hormones
Phenobarbital The enzyme inducer decreases the effect of hormones
Phenytoin The enzyme inducer decreases the effect of hormones
Prednisolone The estrogenic agent increases the effect of corticosteroid
Prednisone The estrogenic agent increases the effect of corticosteroid
Primidone The enzyme inducer decreases the effect of hormones
Raloxifene Association not recommended
Secobarbital The enzyme inducer decreases the effect of hormones
Talbutal The enzyme inducer decreases the effect of hormones
Ursodeoxycholic acid Estrogens decreases the effect of ursodiol

Premarin Food Interactions:

Avoid alcohol.
Take with food to reduce nausea.
Avoid excessive quantities of coffee or tea (Caffeine).

Premarin Generic Name:

Synonyms:

  • Estrone Estrone Hydrogen Sulfate
  • Estrogens
  • Estrone-sulfate
  • Estrone Sulphate
  • Estrone Sulfate Sodium
  • Estrone Sulfate
  • Estrone Sodium Sulfate
  • Estrone Hydrogen Sulfate
  • Oestrone Sulphate
  • Sodium Estrone Sulfate

Drug Type:

Small Molecule; Approved

Absorption:

Well absorbed

Toxicity (Overdose):

Nausea and vomiting

Protein Binding:

90% bound to plasma proteins

Biotransformation:

Hepatic

Half Life:

7.4 hours

Dosage Forms of Premarin:

Powder, for solution Intravenous
Tablet Oral
Cream Topical

Chemical IUPAC Name:

sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate

Organisms Affected:

Humans and other mammals

Premarin to general, pharmacology

General, pharmacology..
Women's Health