Profenid Indication:

For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia and for the management of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Profenid Mechanism Of Action:

Profenid is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and leukotriene synthesis, to have antibrady-kinin activity, as well as to have lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Profenid Drug Interactions:

Alendronate Increased risk of gastric toxicity
Methotrexate The NSAID increases the effect and toxicity of methotrexate
Cyclosporine Monitor for nephrotoxicity
Anisindione The NSAID increases the anticoagulant effect
Acenocoumarol The NSAID increases the anticoagulant effect
Dicumarol The NSAID increases the anticoagulant effect
Warfarin The NSAID increases the anticoagulant effect

Profenid Food Interactions:

Take with food to reduce irritation, avoid alcohol.

Profenid Generic Name:

Synonyms:

  • m-Benzoylhydratropic acid

Drug Type:

Small Molecule; Approved

Absorption:

Ketoprofen is rapidly and well-absorbed orally, with peak plasma levels occurring within 0.5 to 2 hours.

Toxicity (Overdose):

LD50=62.4 mg/kg (rat, oral) Adverse effects from overdose include breathing difficulty, coma, convulsions, drowsiness, high blood pressure, kidney failure, low blood pressure, nausea, sluggishness, stomach and intestinal bleeding, stomach pain, vomiting.

Protein Binding:

99%

Biotransformation:

Not Available

Half Life:

2-2.5 hours

Dosage Forms of Profenid:

Tablet, extended release Oral
Tablet, coated Oral
Suppository Rectal
Capsule Oral

Chemical IUPAC Name:

2-[3-(benzoyl)phenyl]propanoic acid

Organisms Affected:

Humans and other mammals

Profenid to general, pharmacology

General, pharmacology..