Prolixin Indication:

For management of manifestations of psychotic disorders.

Prolixin Mechanism Of Action:

Prolixin blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Prolixin Drug Interactions:

Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Atomoxetine This CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Benzphetamine Decreased anorexic effect, may increase psychotic symptoms
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine The agent decreases the effect of guanethidine
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms

Prolixin Food Interactions:

Avoid alcohol.
Take with food to reduce irritation.

Prolixin Generic Name:

Synonyms:

  • Triflumethazine
  • Fluphenazine Hcl
  • Fluphenazine Decanoate
  • Fluorphenazine
  • Fluorophenazine
  • Fluorfenazine

Drug Type:

Small Molecule; Approved

Absorption:

Not Available

Toxicity (Overdose):

Not Available

Protein Binding:

Not Available

Biotransformation:

Not Available

Half Life:

Not Available

Dosage Forms of Prolixin:

Tablet Oral
Elixir Oral
Liquid Intramuscular

Chemical IUPAC Name:

2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol

Organisms Affected:

Humans and other mammals

Prolixin to general, pharmacology

General, pharmacology..