Protonix

Protonix is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

Medicinal name:
  • Pantoprazole 20 MG Delayed Release Oral Tablet [Protonix]
  • Pantoprazole 40 MG Delayed Release Oral Tablet [Protonix]

Protonix - Pharmacology:

Protonix is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

Protonix mini report

Protonix NDA
NDA - A product marketed under an approved New Drug Application
Protonix ORAL
ORAL
Protonix INTRAVENOUS
INTRAVENOUS
Protonix GRANULE, DELAYED RELEASE
GRANULE, DELAYED RELEASE
Protonix INJECTION, POWDER, FOR SOLUTION
INJECTION, POWDER, FOR SOLUTION
Protonix TABLET, DELAYED RELEASE
TABLET, DELAYED RELEASE
Protonix HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Protonix global name
PANTOPRAZOLE SODIUM
Protonix global name
pantoprazoel sodium
Protonix global name
pantoprazole sodium
Start - Stop data
START DATA:
2008-Feb-29
Start - Stop data
STOP DATA
not occurred

Protonix for patients

Patients should be cautioned that PROTONIX Delayed-Release Tablets should not be split, crushed or chewed. The tablets should be swallowed whole, with or without food in the stomach. Concomitant administration of antacids does not affect the absorption of pantoprazole.

Protonix Interactions

Protonix is metabolized through the cytochrome P450 system, primarily the CYP2C19 and CYP3A4 isozymes, and subsequently undergoes Phase II conjugation.

Based on studies evaluating possible interactions of pantoprazole with other drugs, no dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam (and its active metabolite, desmethyldiazepam), diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, an oral contraceptive (levonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole, or amoxicillin. Clinically relevant interactions of pantoprazole with other drugs with the same metabolic pathways are not expected. Therefore, when coadministered with pantoprazole, adjustment of the dosage of pantoprazole or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time.

Because of profound and long lasting inhibition of gastric acid secretion, pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (eg, ketoconazole, ampicillin esters, and iron salts).

Laboratory Tests

There have been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving most proton pump inhibitors, including pantoprazole. An alternative confirmatory method should be considered to verify positive results.

Protonix Contraindications

PROTONIX Delayed- Release Tablets are contraindicated in patients with known hypersensitivity to any component of the formulation.

 

Manufacturers name:

  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Rebel Distributors Corp
  • STAT RX USA LLC
  • Cardinal Health
  • Physicians Total Care, Inc
  • Wyeth Pharmaceuticals Inc, a subsidiary of Pfizer Inc

Protonix tags categories:

Generic name, Overdose, Half Life Protonix, Food Interactions, Chemical, etc..

Protonix see also FDA report Saw Palmetto

Brand Names containing Pantoprazole
Gastro Health