Prozac Indication:

For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.

Prozac Mechanism Of Action:

Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Prozac Drug Interactions:

Almotriptan Increased risk of CNS adverse effects
Eletriptan Increased risk of CNS adverse effects
Frovatriptan Increased risk of CNS adverse effects
Zolmitriptan Increased risk of CNS adverse effects
Naratriptan Increased risk of CNS adverse effects
Rizatriptan Increased risk of CNS adverse effects
Sumatriptan Increased risk of CNS adverse effects
Amitriptyline Prozac increases the effect and toxicity of tricyclics
Amoxapine Prozac increases the effect and toxicity of tricyclics
Clomipramine Prozac increases the effect and toxicity of tricyclics
Desipramine Prozac increases the effect and toxicity of tricyclics
Doxepin Prozac increases the effect and toxicity of tricyclics
Imipramine Prozac increases the effect and toxicity of tricyclics
Nortriptyline Prozac increases the effect and toxicity of tricyclics
Protriptyline Prozac increases the effect and toxicity of tricyclics
Trimipramine Prozac increases the effect and toxicity of tricyclics
Phenytoin Prozac increases the effect of phenytoin
Mephenytoin Prozac increases the effect of phenytoin
Ethotoin Prozac increases the effect of phenytoin
Fosphenytoin Prozac increases the effect of phenytoin
Amphetamine Risk of serotoninergic syndrome
Benzphetamine Risk of serotoninergic syndrome
Dextroamphetamine Risk of serotoninergic syndrome
Dexfenfluramine Risk of serotoninergic syndrome
Diethylpropion Risk of serotoninergic syndrome
Fenfluramine Risk of serotoninergic syndrome
Mazindol Risk of serotoninergic syndrome
Methamphetamine Risk of serotoninergic syndrome
Moclobemide Risk of serotoninergic syndrome
Phendimetrazine Risk of serotoninergic syndrome
Phentermine Risk of serotoninergic syndrome
Phenylpropanolamine Risk of serotoninergic syndrome
Sibutramine Risk of serotoninergic syndrome
Anisindione The SSRI increases the effect of anticoagulant
Dicumarol The SSRI increases the effect of anticoagulant
Acenocoumarol The SSRI increases the effect of anticoagulant
Warfarin The SSRI increases the effect of anticoagulant
Carvedilol The SSRI increases the effect of the beta-blocker
Lithium The SSRI increases serum levels of lithium
Metoprolol The SSRI increases the effect of the beta-blocker
Propranolol The SSRI increases the effect of the beta-blocker
Risperidone The SSRI increases the effect and toxicity of risperidone
Astemizole Increased risk of cardiotoxicity and arrhythmias
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Carbamazepine Increases the effect of carbamazepine
Cilostazol Increases the effect of cilostazol
Clozapine The antidepressant increases the effect of clozapine
Cyclosporine The antidepressant increases the effect and toxicity of cyclosporine
Clarithromycin Possible serotoninergic syndrome with this combination
Erythromycin Possible serotoninergic syndrome with this combination
Josamycin Possible serotoninergic syndrome with this combination
Cyproheptadine Possible antagonism of action
Dextromethorphan Combination associated with possible serotoninergic syndrome
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Ergotamine Possible ergotism and severe ischemia with this combination
Isocarboxazid Possible severe adverse reaction with this combination
Phenelzine Possible severe adverse reaction with this combination
Rasagiline Possible severe adverse reaction with this combination
Selegiline Possible severe adverse reaction with this combination
Tranylcypromine Possible severe adverse reaction with this combination
Troleandomycin Possible serotoninergic syndrome with this combination
Linezolid Combination associated with possible serotoninergic syndrome
Oxycodone Increased risk of serotonin syndrome
Propafenone Increases the effect and toxicity of propafenone
Ritonavir Increased risk of serotonin syndrome
St. John's Wort St. John's Wort increases the effect and toxicity of the SSRI
Tramadol Increased risk of serotonin syndrome

Prozac Food Interactions:

Take with food to reduce irritation and nausea.
Avoid alcohol.

Prozac Generic Name:

Synonyms:

  • Fluoxetinum [Inn-Latin]
  • Fluoxetine Hydrochloride
  • Fluoxetine Hcl
  • Fluoxetina [Spanish]
  • Fluoxetina [Inn-Spanish]

Drug Type:

Small Molecule; Approved

Absorption:

72%

Toxicity (Overdose):

Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).

Protein Binding:

94.5%

Biotransformation:

Hepatic.

Half Life:

1 to 3 days

Dosage Forms of Prozac:

Liquid Oral
Capsule Oral
Solution Oral

Chemical IUPAC Name:

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

Organisms Affected:

Humans and other mammals

Prozac to general, pharmacology

General, pharmacology..
Antidepressants