Drugs which may enhance the neuromuscular blocking action of succinylcholine include: promazine,
oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, b-adrenergic blockers,
procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, diethylether,
isoflurane, desflurane, metoclopramide, and terbutaline. The neuromuscular blocking effect of succinylcholine may be
enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives,
glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma
If other neuromuscular blocking agents are to be used during the same procedure, the possibility of a
synergistic or antagonistic effect should be considered.