Revia Indication:

For use in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids.

Revia Mechanism Of Action:

Revia binds to the opioid mu receptor antagonistically, thereby preventing conventional opiate (heroin, morphine) drugs from binding and inducing opioid neural responses. The mechanism of action of naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Revia competitively binds to such receptors and may block the effects of endogenous opioids.

Revia Drug Interactions:

Alfentanil Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Buprenorphine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Codeine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Dihydrocodeine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Fentanyl Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Heroin Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Hydrocodone Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Hydromorphone Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Levorphanol Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Meperidine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Methadone Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Morphine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Nalbuphine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Sufentanil Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Propoxyphene Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Pentazocine Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Oxymorphone Revia may precipitate a withdrawal syndrome in opioid-dependent individuals
Oxycodone Revia may precipitate a withdrawal syndrome in opioid-dependent individuals

Revia Food Interactions:

Not Available

Revia Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

Although well absorbed orally, naltrexone is subject to significant first pass metabolism with oral bioavailability estimates ranging from 5 to 40%.

Toxicity (Overdose):

In the mouse, rat and guinea pig, the oral LD50s were 1,100-1,550 mg/kg; 1,450 mg/kg; and 1,490 mg/kg; respectively. High doses of naltrexone (generally ≥1,000 mg/kg) produce salivation, depression/reduced activity, tremors, and convulsions.

Protein Binding:

21% bound to plasma proteins over the therapeutic dose range.

Biotransformation:

Hepatic. When administered orally, naltrexone undergoes extensive biotransformation and is metabolized to 6 beta-naltrexol (which may contribute to the therapeutic effect) and other minor metabolites.

Half Life:

4 hours for naltrexone and 13 hours for the active metabolite 6 beta-naltrexol.

Dosage Forms of Revia:

Tablet Oral

Chemical IUPAC Name:

Not Available

Organisms Affected:

Humans and other mammals

Revia to general, pharmacology

General, pharmacology..
General health