SIM

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha.

Medicinal name:
  • Simvastatin 40 MG Oral Tablet
  • Simvastatin 10 MG Oral Tablet
  • Simvastatin 20 MG Oral Tablet
  • Simvastatin 20 MG Disintegrating Oral Tablet
  • Simvastatin 5 MG Oral Tablet
  • Simvastatin 80 MG Oral Tablet
  • Simethicone 125 MG Oral Capsule
  • 24 HR Niacin 750 MG / Simvastatin 20 MG Extended Release Oral Tablet [Simcor]
  • Bisacodyl 5 MG Delayed Release Oral Tablet
  • Famotidine 20 MG Oral Tablet
  • Simethicone 80 MG Chewable Tablet
  • Diphenhydramine Hydrochloride 25 MG Oral Tablet [Simply Sleep]
  • 8 HR Acetaminophen 650 MG Extended Release Oral Tablet
  • 24 HR Niacin 500 MG / Simvastatin 20 MG Extended Release Oral Tablet [Simcor]
  • 24 HR Niacin 1000 MG / Simvastatin 20 MG Extended Release Oral Tablet [Simcor]
  • Simethicone 180 MG Oral Capsule
  • 12 HR Guaifenesin 600 MG Extended Release Oral Tablet
  • Cefpodoxime 200 MG Oral Tablet [Simplicef]
  • Lansoprazole 15 MG Delayed Release Oral Capsule
  • Acetaminophen 500 MG Oral Tablet
  • Simvastatin 40 MG Disintegrating Oral Tablet
  • 24 HR Niacin 1000 MG / Simvastatin 40 MG Extended Release Oral Tablet [Simcor]
  • Calcium Carbonate 800 MG / Famotidine 10 MG / Magnesium Hydroxide 165 MG Chewable Tablet
  • Simvastatin 80 MG Disintegrating Oral Tablet
  • Simethicone 250 MG Oral Capsule
  • Simvastatin 10 MG Disintegrating Oral Tablet
  • Loperamide Hydrochloride 2 MG Oral Tablet
  • Loratadine 10 MG Oral Tablet
  • Cetirizine hydrochloride 10 MG Oral Tablet
  • 24 HR Niacin 500 MG / Simvastatin 40 MG Extended Release Oral Tablet [Simcor]
  • Guaifenesin 400 MG Oral Tablet
  • Diphenhydramine Hydrochloride 25 MG Oral Tablet
  • Naproxen sodium 220 MG Oral Capsule
  • Omeprazole 20 MG Delayed Release Oral Tablet
  • Cefpodoxime 100 MG Oral Tablet [Simplicef]
  • Ibuprofen 200 MG Oral Tablet
  • Naproxen sodium 220 MG Oral Tablet

SIM - Pharmacology:

Simulect binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.

SIM Interactions

No dose adjustment is necessary when Simulect®is added to triple-immunosuppression regimens including cyclosporine, corticosteroids, and either azathioprine or mycophenolate mofetil. Three clinical trials have investigated Simulect®use in combination with triple-therapy regimens. Pharmacokinetics were assessed in two of these trials. Total body clearance of Simulect®was reduced by an average 22% and 51% when azathioprine and mycophenolate mofetil, respectively, were added to a regimen consisting of cyclosporine, USP (MODIFIED) and corticosteroids. Nonetheless, the range of individual Simulect®clearance values in the presence of azathioprine (12-57 mL/h) or mycophenolate mofetil (7-54 mL/h) did not extend outside the range observed with dual therapy (10-78 mL/h). The following medications have been administered in clinical trials with Simulect®with no increase in adverse reactions: ATG/ALG, azathioprine, corticosteroids, cyclosporine, mycophenolate mofetil, and muromonab-CD3.

SIM Contraindications

Simulect®is contraindicated in patients with known hypersensitivity to basiliximab or any other component of the formulation. See composition of Simulect® under DESCRIPTION.

Manufacturers name:

  • Preferred Pharmaceuticals, Inc
  • McKesson Packaging Services a business unit of McKesson Corporation
  • Ranbaxy Pharmaceuticals Inc
  • Mylan Institutional Inc
  • Rebel Distributors Corp
  • Dr Reddys Laboratories Limited
  • Lupin Pharmaceuticals, Inc
  • Synthon Pharmaceuticals, Inc
  • Accord Healthcare, Inc
  • Legacy Pharmaceutical Packaging
  • Cardinal Health
  • McKesson Contract Packaging
  • SPIRIT PHARMACEUTICALS,LLC
  • Cobalt Laboratories Inc
  • UDL Laboratories, Inc
  • Physicians Total Care, Inc
  • Bryant Ranch Prepack
  • Mylan Pharmaceuticals Inc
  • State of Florida DOH Central Pharmacy
  • DIRECT RX
  • Unit Dose Services
  • Contract Pharmacy Services-PA
  • Gen-Source Rx
  • Simpex Pharma Pvt Ltd
  • AvPAK
  • St Marys Medical Park Pharmacy
  • Teva Pharmaceuticals USA Inc
  • Micro Labs Limited
  • Carilion Materials Management
  • Blu Pharmaceuticals, LLC
  • Cadila Healthcare Limited
  • Major Pharmaceuticals
  • ReadyMeds
  • Aurobindo Pharma Limited
  • Aphena Pharma Solutions - Tennessee, LLC
  • Aurolife Pharma LLC
  • REMEDYREPACK INC
  • Sams West Inc
  • RxChange Co
  • PD-Rx Pharmaceuticals, Inc
  • Geri-Care Pharmaceuticals, Corp
  • McNeil Consumer Healthcare Div McNeil-PPC, Inc
  • MedVantx, Inc
  • International Labs, Inc
  • AbbVie Inc
  • Ingenus Pharmaceuticals, LLC
  • HJ Harkins Company, Inc
  • Lake Erie Medical DBA Quality Care Products LLC
  • Softech Pharma Pvt Ltd
  • Safecor Health, LLC
  • NCS HealthCare of KY, Inc dba Vangard Labs
  • Zoetis Inc
  • American Health Packaging
  • Northstar Rx LLC
  • Life Line Home Care Services, Inc
  • Clinical Solutions Wholesale
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Proficient Rx LP
  • Humanwell PuraCap Pharmaceutical (Wuhan) Co, Ltd
  • Zydus Pharmaceuticals (USA) Inc
  • Aphena Pharma Solutions - Tennessee, Inc
  • Aidarex Pharmaceuticals LLC
  • Rugby Laboratories Inc
  • Nartex Laboratories
  • KAISER FOUNDATION HOSPITALS
  • Humanwell PuraCap Pharmaceutical (Wuhan), Ltd
  • A&Z Pharmaceutical, Inc

Generic name, Overdose, Half Life SIM, Food Interactions, Chemical, etc..

SIM see also

Brand Names containing Basiliximab