An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. .

STZ - Pharmacology:

Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.

STZ Interactions

ZANOSAR may demonstrate additive toxicity when used in combination with other cytotoxic drugs. STZ has been reported to prolong the elimination half-life of doxorubicin and may lead to severe bone marrow suppression; a reduction of the doxorubicin dosage should be considered in patients receiving ZANOSAR concurrently. The concurrent use of strep-tozocin and phenytoin has been reported in one case to result in reduced streptozocin cytotoxicity.


STZ Contraindications

No specific information is available.


Generic name, Overdose, Half Life STZ, Food Interactions, Chemical, etc..

STZ see also

Brand Names containing Streptozocin