Serophene Indication:

Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome). In some countries, it is also registered for use in men.

Serophene Mechanism Of Action:

Serophene acts by inhibiting the action of estrogen on the gonadotrope cells in the anterior pituitary gland. "Sensing" low estrogen levels, follicle-stimulating hormone release is increased, leading to a higher rate of ovulation and hence pregnancy. Serophene has no apparent progestational, androgenic, or antrandrogenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function.

Serophene Drug Interactions:

Amobarbital The enzyme inducer decreases the effect of hormones
Aprobarbital The enzyme inducer decreases the effect of hormones
Butabarbital The enzyme inducer decreases the effect of hormones
Butalbital The enzyme inducer decreases the effect of hormones
Butethal The enzyme inducer decreases the effect of hormones
Ethotoin The enzyme inducer decreases the effect of hormones
Fosphenytoin The enzyme inducer decreases the effect of hormones
Griseofulvin The enzyme inducer decreases the effect of hormones
Heptabarbital The enzyme inducer decreases the effect of hormones
Hexobarbital The enzyme inducer decreases the effect of hormones
Mephenytoin The enzyme inducer decreases the effect of hormones
Methohexital The enzyme inducer decreases the effect of hormones
Methylphenobarbital The enzyme inducer decreases the effect of hormones
Pentobarbital The enzyme inducer decreases the effect of hormones
Phenobarbital The enzyme inducer decreases the effect of hormones
Phenytoin The enzyme inducer decreases the effect of hormones
Primidone The enzyme inducer decreases the effect of hormones
Secobarbital The enzyme inducer decreases the effect of hormones
Talbutal The enzyme inducer decreases the effect of hormones
Prednisolone The estrogenic agent increases the effect of corticosteroid
Prednisone The estrogenic agent increases the effect of corticosteroid
Raloxifene Association not recommended
Ursodeoxycholic acid Estrogens decreases the effect of ursodiol

Serophene Food Interactions:

Take without regard to meals.

Serophene Generic Name:

Synonyms:

  • Clomifene citrate
  • Chloramiphene
  • Chloramifene
  • Chlomaphene
  • Cisclomiphene
  • Clomiphene Citrate
  • Clomifeno
  • Clomiphene citrate (Z,E)
  • Clomiphene dihydrogen citrate
  • Racemic clomiphene citrate
  • Zuclomiphene citrate

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

Based on early studies with 14 C-labeled clomifene, the drug was shown to be readily absorbed orally in humans.

Toxicity (Overdose):

The acute oral LD50 of clomifene is 1700 mg/kg in mice and 5750 mg/kg in rats. The toxic dose in humans is not known. Toxic effects accompanying acute overdosage of clomifene have not been reported. Signs and symptoms of overdosage as a result of the use of more than the recommended dose during clomifene therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain.

Protein Binding:

Not Available

Biotransformation:

Hepatic

Half Life:

5-7 days

Dosage Forms of Serophene:

Tablet Oral

Chemical IUPAC Name:

2-[4-[(Z)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine

Organisms Affected:

Humans and other mammals

Serophene to general, pharmacology

General, pharmacology..