Strattera Indication:

For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD).

Strattera Mechanism Of Action:

The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter, as determined in ex vivo uptake and neurotransmitter depletion studies.

Strattera Drug Interactions:

Amiodarone The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Chloroquine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Diphenhydramine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Fluoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Fluphenazine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Haloperidol The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Isocarboxazid Possible severe adverse reaction with this combination
Lomustine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Mibefradil The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Paroxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Perphenazine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Phenelzine Possible severe adverse reaction with this combination
Primaquine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Propafenone The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Propoxyphene The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinacrine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinidine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinidine barbiturate The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Rasagiline Possible severe adverse reaction with this combination
Ritonavir The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Terbinafine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Thioridazine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Vinorelbine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Tranylcypromine Possible severe adverse reaction with this combination
Yohimbine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine

Strattera Food Interactions:

Take without regard to meals.
In the presence of food, the absorption rate is reduced, without the quantity absorbed being affected.

Strattera Generic Name:

Synonyms:

  • Tomoxetina [Spanish]
  • Tomoxetine
  • Tomoxetine [INN]
  • Tomoxetinum [Latin]

Drug Type:

Small Molecule; Approved

Absorption:

Atomoxetine is rapidly absorbed after oral administration, with absolute bioavailability of about 63% in EMs and 94% in PMs. Drugs that elevate gastric pH (magnesium hydroxide/aluminum hydroxide, omeprazole) have no effect on atomoxetine bioavailability. Absorption is minimally affected by food.

Toxicity (Overdose):

The most commonly reported symptoms accompanying acute and chronic overdoses are somnolence, agitation, hyperactivity, abnormal behavior, and gastrointestinal symptoms.

Protein Binding:

At therapeutic concentrations, 98% of atomoxetine in plasma is bound to protein, primarily albumin.

Biotransformation:

Atomoxetine is primarily metabolized by the CYP2D6 pathway to 4-hydroxyatomoxetine. 4-Hydroxyatomoxetine is equipotent to atomoxetine as an inhibitor of the norepinephrine transporter but circulates in plasma at much lower concentrations (1% of atomoxetine concentration in EMs and 0.1% of atomoxetine concentration in PMs).

Half Life:

5 hours

Dosage Forms of Strattera:

Capsule Oral
Capsule Oral
Capsule Oral
Capsule Oral
Capsule Oral
Capsule Oral

Chemical IUPAC Name:

(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine

Organisms Affected:

Humans and other mammals

Strattera to general, pharmacology

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