Sulfametizol [Inn-Spanish] - General Information:A sulfathiazole antibacterial agent. [PubChem]
Other Brand Names containing Sulfamethizole
Sulfametizol [Inn-Spanish] - Pharmacology:
Sulfametizol [Inn-Spanish] is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Sulfametizol [Inn-Spanish] for patients
Take the drug with a full glass of water on an empty stomach. Increase fluid intake to 2L/day. Store in a tight, light-sensitive container at room temperature. Avoid sunlight or use sunscreen to prevent burns (avoid sunscreens containing PABA), avoid over-the-counter medications unless directed by a physician. Notify your doctor of skin rash, sore throat, fever, mouth sores, unusual bruising, and bleeding.
Sulfametizol [Inn-Spanish] Interactions
Sulfamethizole may increase the effects of barbiturates, tolbutamide, and uricosurics. It may also interact with thiazides (increased thrombocytopenia), cyclosporine (increased nephrotoxicity), sulfonylurea agents (increased hypoglycemic response), warfarin (increased anticoagulant effect), methotrexate (decreased renal excretion of methotrexate), phenytoin (decreased hepatic clearance of phenytoin).
Sulfametizol [Inn-Spanish] Contraindications
Treatment with Sulfamethizole is contraindicated in the following: hypersensitivity to sulfonamides and sulfonylureas, thiazide and loop diuretics, salicyclates, sunscreen with PABA, lactation, infants less than 2 months old, pregnancy at term, and porphyria.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..