Synkavite - General Information:

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. [PubChem]

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Other Brand Names containing Menadione

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Synkavite - Pharmacology:

Synkavite (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body. These proteins include the vitamin K-dependent coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor), X (Stuart factor), protein C, protein S, protein Zv and a growth-arrest-specific factor (Gas6). In contrast to the other vitamin K-dependent proteins in the blood coagulation cascade, protein C and protein X serve anticoagulant roles. The two vitamin K-dependent proteins found in bone are osteocalcin, also known as bone G1a (gamma-carboxyglutamate) protein or BGP, and the matrix G1a protein or MGP. Gamma-carboxylation is catalyzed by the vitamin K-dependent gamma-carboxylases. The reduced form of vitamin K, vitamin K hydroquinone, is the actual cofactor for the gamma-carboxylases. Proteins containing gamma-carboxyglutamate are called G1a proteins.

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Synkavite Interactions

Broad-Spectrum Antibiotics-Broad-spectrum antibiotics may sterilize the bowel and decrease the vitamin K contribution to the body by the intestinal microflora. Cephalosporins-Cephalosporins containing side chains of N-methylthiotetrazole (cefmenoxime, cefoperazone, cefotetan, cefamandole, latamoxef) or methylthiadiazole (cefazolin) can cause vitamin K deficiency and hypoprothrombinemia. These cephalosporins are inhibitors of hepatic vitamin K epoxide reductase. Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K. Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K. Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K. Orlistat-Orlistat may decrease the absorption of vitamin K. Salicylates-Salicylates in large doses may inhibit vitamin K epoxide reductase resulting in vitamin K deficiency. Warfarin-Vitamin K can antagonize the effect of warfarin

Synkavite Contraindications

  • Vitamin K is contraindicated in those hypersensitive to any component of a vitamin K-containing product.
  • Contraindicated in patients with severe hepatic disease.
  • Contraindicated in women in the last few weeks of pregnancy.

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