THE

A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. .
[PubChem].

THE - Pharmacology:

In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.

THE for patients

THE supplementation should be avoided by pregnant women and nursing mothers. Because of some conversion of glycine to ammonia, those with hepatic impairment should avoid glycine supplementation unless prescribed. Interactions: Antispastic drugs. Theoretically, supplemental glycine might have additive effects when used in conjunction with baclofen, diazepam, dantrolene sodium and tizanidine.

THE Interactions

Data is temporarily not available

THE Contraindications

THE supplementation is contraindicated in those hypersensitive to any component of the preparation. It is also contraindicated in those who are anuric (some glycine gets converted to ammonia).

Manufacturers name:

  • Physician Therapeutics LLC
  • Bryant Ranch Prepack
  • Rhodes Pharmaceuticals LP
  • Alembic Pharmaceuticals Limited
  • Cardinal Health
  • Preferred Pharmaceuticals, Inc
  • Novartis Consumer Health, Inc
  • Lake Erie Medical DBA Quality Care Products LLC
  • Bayer HealthCare Consumer Care
  • Physicians Total Care, Inc
  • UCB, Inc
  • Inwood Laboratories, Inc
  • PACK Pharmaceuticals, LLC
  • Heritage Pharmaceuticals Inc
  • State of Florida DOH Central Pharmacy
  • A-S Medication Solutions LLC
  • Major Pharmaceuticals
  • Pliva Inc
  • NCS HealthCare of KY, Inc dba Vangard Labs
  • 3M Pharmaceuticals
  • AvKARE, Inc
  • REMEDYREPACK INC
  • Actient Pharmaceuticals LLC
  • Carilion Materials Management
  • Nostrum Laboratories, Inc
  • Clinical Solutions Wholesale
  • Glenmark Generics Inc, USA
  • The Medicine Shoppe International
  • American Health Packaging
  • Medicine Shoppe International Inc

Generic name, Overdose, Half Life THE, Food Interactions, Chemical, etc..

THE see also Anise

Asthma
Brand Names containing Glycine