Tapazole

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. .
[PubChem].

Medicinal name:
  • Methimazole 10 MG Oral Tablet [Tapazole]
  • Methimazole 5 MG Oral Tablet [Tapazole]

Tapazole - Pharmacology:

Tapazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones.

Tapazole mini report

Tapazole ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Tapazole HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
2000-Mar-31
Start - Stop data
STOP DATA
not occurred

Tapazole for patients

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Tapazole Interactions

Anticoagulants (oral): The activity of oral anticoagulants may be potentiated by anti-vitamin-K activity attributed to methimazole.

ß-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta ratio. A dose reduction of beta-adrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid.

Digitalis glycosides: Serum digitalis levels may be increased when hyperthyroid patients on a stable digitalis glycoside regimen become euthyroid; reduced dosage of digitalis glycosides may be required.

Theophylline: Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.

 

Tapazole Contraindications

Tapazole is contraindicated in the presence of hypersensitivity to the drug and in nursing mothers because the drug is excreted in milk.

Manufacturers name:

  • Pfizer Laboratories Div Pfizer Inc
  • REMEDYREPACK INC

Generic name, Overdose, Half Life Tapazole, Food Interactions, Chemical, etc..

Tapazole see also FDA report

Brand Names containing Methimazole