Teslac - General Information:

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. [PubChem]

Other Brand Names containing Testolactone

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Teslac - Pharmacology:

Although the precise mechanism by which testolactone produces its clinical antineoplastic effects has not been established, its principal action is reported to be inhibition of steroid aromatase activity and consequent reduction in estrone synthesis from adrenal androstenedione, the major source of estrogen in postmenopausal women. Based on in vitro studies, the aromatase inhibition may be noncompetitive and irreversible. This phenomenon may account for the persistence of testolactone's effect on estrogen synthesis after drug withdrawal.

Teslac for patients

The physician should be consulted regarding missed doses. Notify the physician if adverse reactions occur or become more pronounced.

Teslac Interactions

When administered concurrently, testolactone may increase the effects of oral anticoagulants; monitor and adjust anticoagulant dosage accordingly.

Drug/Laboratory Test Interactions:   Physiologic effects of testolactone may result in decreased estradiol concentrations with radioimmunoassays for estradiol, increased plasma calcium concentrations, and increased 24-hour urinary excretion of creatine and 17-ketosteroids.

Teslac Contraindications

Testolactone is contraindicated in the treatment of breast cancer in men and in patients with a history of hypersensitivity to the drug.

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