Tigan is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Medicinal name:
  • Trimethobenzamide hydrochloride 300 MG Oral Capsule [Tigan]
  • Tigan 300 MG Oral Capsule

Tigan - Pharmacology:

The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.

Tigan Interactions

No specific information available.


Tigan Contraindications

Use of the injectable form of Tigan® in children, the suppositories in premature or newborn infants, and use of any dosage form in patients with known hypersensitivity to trimethobenzamide are contraindicated. Since the suppositories contain benzocaine they should not be used in patients known to be sensitive to this or similar local anesthetics.

Manufacturers name:

  • Pfizer Laboratories Div Pfizer Inc
  • Monarch Pharmaceuticals, Inc

Tigan more info

Generic name, Overdose, Half Life Tigan, Food Interactions, Chemical, etc..
Brand Names containing Trimethobenzamide