Trileptal Indication:

For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.

Trileptal Mechanism Of Action:

The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.

Trileptal Drug Interactions:

Cyclosporine Trileptal decreases the effect of cyclosporine
Felodipine Trileptal decreases the levels of felodipine
Mestranol Trileptal decreases the effect of the contraceptive
Ethinyl Estradiol Trileptal decreases the effect of the contraceptive
Ethotoin Trileptal increases the effect of hydantoin
Fosphenytoin Trileptal increases the effect of hydantoin
Mephenytoin Trileptal increases the effect of hydantoin
Phenytoin Trileptal increases the effect of hydantoin

Trileptal Food Interactions:

Not Available

Trileptal Generic Name:

Synonyms:

  • Oxcarbamazepine

Drug Type:

Small Molecule; Approved

Absorption:

Completely absorbed following oral administration. Food has no effect on the rate and extent of absorption of oxcarbazepine.

Toxicity (Overdose):

Isolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment.

Protein Binding:

Approximately 40% of the active 10-monohydroxy metabolite (MHD) is bound to serum proteins, predominantly to albumin. Neither oxcarbazepine nor its MHD binds with alpha-1–acid blycoprotein.

Biotransformation:

Oxcarbazepine is completely absorbed and extensively metabolized to its pharmacologically active 10-monohydroxy metabolite (MHD). MHD is metabolized further by conjugation with glucuronic acid.

Half Life:

The half-life of the parent is about 2 hours, while the half-life of MHD is about 9 hours, so that MHD is responsible for most anti-epileptic activity.

Dosage Forms of Trileptal:

Tablet Oral
Suspension Oral

Chemical IUPAC Name:

5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide

Organisms Affected:

Humans and other mammals

Trileptal to general, pharmacology

General, pharmacology..
General health