Ulo

One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. .
[PubChem].

Medicinal name:
  • Febuxostat 80 MG Oral Tablet [Uloric]
  • Febuxostat 40 MG Oral Tablet [Uloric]

Ulo - Pharmacology:

Ulo inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

Ulo for patients

Patients should be warned that at the first appearance of a skin rash they should stop use of Ulo and seek medical attention immediately. Patients should also be warned that the appearance of sore throat, pallor, purpura, or glossitis may be early indications of serious disorders which require treatment with Ulo to be stopped and medical treatment to be sought.

Women of childbearing potential who are taking Ulo should be warned against becoming pregnant. Patients should be warned to keep DARAPRIM out of the reach of children. Patients should be advised not to exceed recommended doses. Patients should be warned that if anorexia and vomiting occur, they may be minimized by taking the drug with meals.

Concurrent administration of folinic acid is strongly recommended when used for the treatment of toxoplasmosis in all patients.

Ulo Interactions

Ulo may be used with sulfonamides, quinine and other antimalarials, and with other antibiotics. However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfon-amides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrex-ate) while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. If signs of folate deficiency develop, pyrimethamine should be discontinued. Folinic acid (leucovorin) should be administered until normal hematopoiesis is restored. Mild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine were administered concomitantly.

Ulo Contraindications

Use of DARAPRIM is contraindicated in patients with known hypersensitivity to pyrimethamine or to any component of the formulation. Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency.

Manufacturers name:

  • Rebel Distributors Corp
  • Takeda Pharmaceuticals America, Inc
  • REMEDYREPACK INC

Generic name, Overdose, Half Life Ulo, Food Interactions, Chemical, etc..

Ulo see also

Brand Names containing Pyrimethamine