Uroxatral Indication:

For the treatment of the signs and symptoms of benign prostatic hyperplasia.

Uroxatral Mechanism Of Action:

Uroxatral acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Uroxatral Drug Interactions:

Itraconazole The antifungal increases the effect of alfuzosin
Ketoconazole The antifungal increases the effect of alfuzosin
Ritonavir Ritonavir increases the effect/toxicity of alfuzosin
Vardenafil Risk of significant hypotension with this association

Uroxatral Food Interactions:

Take after a meal (always the same meal), product bioavailability is reduced when taken on an empty stomach.

Uroxatral Generic Name:

Synonyms:

  • Alfusosine

Drug Type:

Small Molecule; Approved

Absorption:

Absorption is 50% lower under fasting conditions

Toxicity (Overdose):

Side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.

Protein Binding:

82%-90%

Biotransformation:

Hepatic. Alfuzosin undergoes extensive metabolism by the liver, with only 11% of the administered dose excreted unchanged in the urine. Alfuzosin is metabolized by three metabolic pathways: oxidation, O-demethylations, and N-dealkylation. The metabolites are not pharmacologically active. CYP3A4 is the principal hepatic enzyme isoform involved in its metabolism.

Half Life:

10 hours

Dosage Forms of Uroxatral:

Tablet, extended release Oral

Chemical IUPAC Name:

N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide

Organisms Affected:

Humans and other mammals

Uroxatral to general, pharmacology

General, pharmacology..
Men's Health