Viagra Indication:

For the treatment of erectile dysfunction

Viagra Mechanism Of Action:

Viagra inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Viagra enhances erectile function by increasing the amount of cGMP.

Viagra Drug Interactions:

Not Available

Viagra Food Interactions:

Take on empty stomach: 1 hour before or 2 hours after meals.

Viagra Generic Name:

Synonyms:

  • Sildenafil Citrate

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

~40%

Toxicity (Overdose):

Not Available

Protein Binding:

96%

Biotransformation:

Hepatic

Half Life:

4 hours

Dosage Forms of Viagra:

Tablet Oral

Chemical IUPAC Name:

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one

Organisms Affected:

Humans and other mammals

Viagra to general, pharmacology

General, pharmacology..