Viramune Indication:

For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.

Viramune Mechanism Of Action:

Viramune binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.

Viramune Drug Interactions:

Anisindione Viramune decreases the anticoagulant effect
Acenocoumarol Viramune decreases the anticoagulant effect
Dicumarol Viramune decreases the anticoagulant effect
Warfarin Viramune decreases the anticoagulant effect
Atazanavir Decreases levels/effect of atazanavir
Ketoconazole Decreases the effect of ketoconazole
St. John's Wort St. John's Wort decreases nevirapine effect
Saquinavir Decreases the effect of saquinavir
Quinupristin This combination presents an increased risk of toxicity
Nelfinavir Decreases the effect of nelfinavir
Methadone The antiretroviral agent decreases the effect of methadone
Atorvastatin The NNRT inhibitor increases the effect and toxicity of the statin
Lovastatin The NNRT inhibitor increases the effect and toxicity of the statin
Simvastatin The NNRT inhibitor increases the effect and toxicity of the statin

Viramune Food Interactions:

Not Available

Viramune Generic Name:

Synonyms:

  • NEV
  • NVP

Drug Type:

Small Molecule; Approved

Absorption:

90% (absolute bioavailability 93 ± 9%)

Toxicity (Overdose):

Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease.

Protein Binding:

60%

Biotransformation:

Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.

Half Life:

45 hours

Dosage Forms of Viramune:

Tablet Oral

Chemical IUPAC Name:

1-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido [3,2-b:2',3'-e][1,4] diazepin-6-one

Organisms Affected:

Human Immunodeficiency Virus

Viramune to general, pharmacology

General, pharmacology..
General health